Status:
COMPLETED
Heritability of Opioid Effects: A Twin Study
Lead Sponsor:
Martin Angst
Collaborating Sponsors:
SRI International
Conditions:
Pain
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Proposed twin study will test to what degree inter-individual differences in pain sensitivity and amount of pain relief in response to opioid therapy are inherited or alternatively, are due to environ...
Detailed Description
The principal hypothesis to be evaluated is that the degree of analgesia provided by opioids in humans displays substantial familial aggregation, and is, in fact, heritable. These studies will use a c...
Eligibility Criteria
Inclusion
- Monozygotic or dizygotic twins ages 18-70
Exclusion
- (1) Clinically relevant systemic diseases such as psychiatric, neurological, and dermatological conditions interfering with the collection and interpretation of study data (2) History of addiction (3) Allergy to study medication (4) Chronic intake of medication potentially interfering with pain processing (except oral contraceptives) (5) Intake of over-the-counter analgesics within the two days prior to study (6) Reynaud's disease (7) Pregnancy (8) Participation in other study within last 30 days (9) Personnel with direct access to addicting drugs
Key Trial Info
Start Date :
May 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2010
Estimated Enrollment :
242 Patients enrolled
Trial Details
Trial ID
NCT00672438
Start Date
May 1 2008
End Date
June 1 2010
Last Update
January 6 2017
Active Locations (1)
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1
Stanford University School of Medicine
Stanford, California, United States, 94305