Status:
TERMINATED
Organ Donation and Hydrocortisone Treatment
Lead Sponsor:
Kuopio University Hospital
Collaborating Sponsors:
Tampere University Hospital
Conditions:
Brain Death
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Brain death patients who are selected for organ donation very often suffer from haemodynamic instability. To treat this, high amounts of vasoactive drugs(norepinephrine) may be needed to raise blood p...
Detailed Description
When patients are treated in the ICU only as possible organ donators they will be assessed for eligibility for the study. Iv hydrocortisone or placebo will be administered every 6 hours. Several hormo...
Eligibility Criteria
Inclusion
- all have to be fulfilled
- severe brain injury or subarachnoid hemorrhage which progrediates to brain death and patients are treated only as candidates for organ donation in the ICU
- no other reasons for treatment than organ donation
- informed consent from official representative
Exclusion
- age under 18
- pregnancy
- corticoid treatment before study entry
- adrenal insufficiency
- hypophyseal insufficiency
- treatment with etomidate one week before study entry
- participating in an other study
- no informed consent
Key Trial Info
Start Date :
May 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
38 Patients enrolled
Trial Details
Trial ID
NCT00675272
Start Date
May 1 2008
End Date
December 1 2011
Last Update
April 6 2015
Active Locations (2)
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1
Kuopio University Hospital
Kuopio, Finland, 70211
2
Tampere University Hospital
Tampere, Finland