Status:
COMPLETED
Daily Sedative Interruption in Critically Ill Patients Being Managed With a Sedation Protocol.
Lead Sponsor:
Mount Sinai Hospital, Canada
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
Ottawa Hospital Research Institute
Conditions:
Critical Illness
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to determine whether the use of both a nurse-driven sedation protocol and daily sedative interruption, compared with a sedation protocol alone, result in better outcomes f...
Detailed Description
All critically ill, mechanically ventilated patients in the Intensive Care Unit receive medications to relieve pain and anxiety. However, accumulation of these medications can be associated with serio...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- 18 years of age or over
- Mechanically ventilated, with anticipated need for MV ≥48 hrs
- ICU team has decided to initiate continuous sedative/analgesic infusion(s)
- informed consent from patient and/or SDM
- Exclusion Criteria
- Admission after resuscitation from cardiac arrest
- Traumatic brain injury
- Currently receiving neuromuscular blocking agents
- Allergy to midazolam and lorazepam
- Lack of commitment to aggressive treatment
- Previous enrolment in SLEAP, or current enrolment in related trial
Exclusion
Key Trial Info
Start Date :
January 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 17 2012
Estimated Enrollment :
410 Patients enrolled
Trial Details
Trial ID
NCT00675363
Start Date
January 1 2008
End Date
October 17 2012
Last Update
May 9 2025
Active Locations (16)
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1
Long Beach Memorial Medical Center
Long Beach, California, United States
2
Tuft's Medical Centre
Boston, Massachusetts, United States
3
Royal Alexandra Hospital
Edmonton, Alberta, Canada, T5H 3V9
4
Walter C. Mackenzie Health Sciences Centre
Edmonton, Alberta, Canada, T6G 2B7