Status:
COMPLETED
Neurocognitive Correlates of Behavioral Treatment for Childhood Tic Disorders
Lead Sponsor:
John Piacentini
Conditions:
Tic Disorder
Eligibility:
All Genders
9-14 years
Phase:
NA
Brief Summary
The study aims to clarify the functional anatomy of key brain circuits associated with cognitive control in children and adolescents with chronic tic disorders (CTD) and to compare and contrast hypoth...
Eligibility Criteria
Inclusion
- DSM-IV diagnostic criteria for CTD (CMVT or TS)
- Clinical Global Impressions - Severity Score \> 3 (moderately ill or worse)
- YGTSS Total Score \> 14 (or Total Score \> 10 if CTD with motor tics only)
- Unmedicated or on stable psychotropic medication for at least 6 weeks prior to study entry, with no planned changes for duration of study participation
- Child is fluent English speaker
- Parental Informed Consent and Child Informed Assent.
Exclusion
- Total YGTSS Score\>35 (Cases above this threshold otherwise eligible will be reviewed by Clinical Caseness Panel for potential study participation)
- IQ \< 80 on the Wechsler Abbreviated Scale of Intelligence (WASI)
- Problematic Substance Use or DSM-IV Conduct Disorder in past 3 months
- Lifetime DSM-IV diagnosis of PDD, Mania, or Psychotic Disorder
- Any serious psychiatric, psychosocial, or neurological condition requiring immediate treatment other than that provided in the current study
- Previous treatment with four or more sessions of HRT for tics
- Contraindication to fMRI scan
Key Trial Info
Start Date :
July 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
53 Patients enrolled
Trial Details
Trial ID
NCT00675675
Start Date
July 1 2007
End Date
December 1 2011
Last Update
August 21 2015
Active Locations (1)
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1
University of California, Los Angeles
Los Angeles, California, United States, 90024