Status:
COMPLETED
The Optimal Mode of Renal Replacement Therapy in Acute Kidney Injury (OMAKI) Study
Lead Sponsor:
Unity Health Toronto
Collaborating Sponsors:
University of Toronto
Conditions:
Acute Kidney Injury
Eligibility:
All Genders
16+ years
Phase:
PHASE4
Brief Summary
Acute kidney injury (AKI) in the intensive care unit is common, devastating and costly. However, minimal evidence exists to guide the prescription of optimal renal replacement therapy (RRT). An import...
Detailed Description
The optimal mode of clearance in critically ill patients with acute kidney injury (AKI) who require renal replacement therapy (RRT) is unclear. Although both convection (as provided by hemofiltration)...
Eligibility Criteria
Inclusion
- Adult patients (over 16 years of age) admitted to a participating ICU
- Serum creatinine increase of ≥ 50% from baseline
- Hemodynamic instability as defined by the cardiovascular component of the SOFA score of ≥ 1
- Attending physician deems the patient a candidate for RRT for at least one of the following reasons:
- Presence of oliguria, defined as a urine output of \< 100 mL in the preceding 4 hours
- metabolic acidosis (HCO3- \< 15 mmol/L and pH \< 7.25)
- refractory hyperkalemia (K \> 6.0 mmol/L)
- azotemia (BUN \> 50 mmol/L)
- suspected uremic organ involvement (pericarditis, encephalopathy, neuropathy or myopathy)
Exclusion
- renal replacement therapy within the previous 2 months
- presence of renal obstruction
- receipt of a kidney transplant in the previous year
- diagnosis of rapidly progressive glomerulonephritis, vasculitis, or acute interstitial nephritis
- indication for intermittent hemodialysis, specifically severe hyperkalemia, dialyzable drug or toxin
- terminal illness with associated life expectancy less than 2 months
- patients who are moribund
- prior enrollment in this study
- enrollment in a competing ICU interventional study
- no CRRT machine available
- acute renal replacement ongoing for \> 36 hours
Key Trial Info
Start Date :
May 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2010
Estimated Enrollment :
78 Patients enrolled
Trial Details
Trial ID
NCT00675818
Start Date
May 1 2008
End Date
October 1 2010
Last Update
March 12 2012
Active Locations (5)
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1
University of Alberta
Edmonton, Alberta, Canada
2
London Health Sciences Centre
London, Ontario, Canada
3
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5
4
St. Michael's Hospital
Toronto, Ontario, Canada, M5B 1W8