Status:
COMPLETED
A New Approach of Neostigmine in Unavoidable Post Operative Ileus
Lead Sponsor:
Baqiyatallah Medical Sciences University
Conditions:
Ileus
Eligibility:
All Genders
18-76 years
Phase:
PHASE4
Brief Summary
Postoperative ileus (POI) in the absence of any mechanical obstruction remains a commonly encountered clinical problem.So, this study aimed to show the effective way to decrease the rate of postoperat...
Detailed Description
We honestly declare that, the use of parasympathomimetic agents such as neostigmine is not without risk. Patients with underlying bradyarrhythmias or those receiving β-adrenergic antagonists may be mo...
Eligibility Criteria
Inclusion
- Patients with acute colonic pseudo-obstruction who were 18 years of age or older
- Patients had to have a cecal diameter of at least 10 cm on plain radiographs
- Mechanical obstruction was ruled out by the finding of air throughout all colonic segments including the rectosigmoid on plain abdominal radiographs
Exclusion
- Exclusion criteria included a base-line heart rate of less than 60 beats per minute or systolic blood pressure of less than 90 mm Hg; signs of bowel perforation
- With peritoneal signs on physical examination or free air on radiographs; active bronchospasm requiring medication
- Treatment with prokinetic drugs such as cisapride or metoclopramide in the 24 hours before evaluation
- A history of colon cancer or partial colonic resection
- Active gastrointestinal bleeding
- Pregnancy
- Positive history of Myocardial Infarction, Intestinal Resection or a serum creatinine concentration of more than 3 mg per deciliter (265 µmol per liter)
Key Trial Info
Start Date :
August 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2008
Estimated Enrollment :
3 Patients enrolled
Trial Details
Trial ID
NCT00676377
Start Date
August 1 2007
End Date
February 1 2008
Last Update
May 13 2008
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Baqyiattalah University of Medical Science
Tehran, Iran