Status:
COMPLETED
Influence of Propofol on Alveolar Macrophage in Asthmatic Patients
Lead Sponsor:
Nanjing Medical University
Collaborating Sponsors:
HRSA/Maternal and Child Health Bureau
Conditions:
Asthma
Eligibility:
FEMALE
18-45 years
Brief Summary
The change of airway responsiveness and alveolar macrophage (AM) immunity occurs during the pathogenesis of asthma. Macrophage-associated airway protection in patients with asthma is affected positive...
Eligibility Criteria
Inclusion
- ASA physical status I-II;
- Aged from 18 years to 45 years;
- Patients with or without asthma or a history record of asthma;
- Undergoing elective lumpectomy under general anesthesia.
Exclusion
- Allergy to propofol and opioids, a history of the use of centrally-acting drugs of any sort, chronic pain and psychiatric diseases records;
- Participants younger than 18yr，older than 45yr or pregnancy;
- Those who were not willing to or could not finish the whole study at any time;
- The PACU assessing score was under 6 on a scale of 10 (measuring somnolence, respiration, movement, color, and blood pressure on 0-2 scales), and arterial oxygen saturation measured by pulse oximetry (SaO2) was 92% or lower (supplemental oxygen was permitted).
Key Trial Info
Start Date :
April 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 1 2009
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT00676416
Start Date
April 1 2008
End Date
March 1 2009
Last Update
March 31 2009
Active Locations (1)
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1
Nanjing Maternal and Child Health Care Hospital
Nanjing, Jiangsu, China, 210004