Status:
COMPLETED
Statin Therapy in the Treatment of Sepsis
Lead Sponsor:
Beth Israel Deaconess Medical Center
Conditions:
Septic Shock
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
Simvastatin will attenutat IL-6 levels and lead to a more rapid shock reversal than placebo
Eligibility Criteria
Inclusion
- Greater than 18 years old
- Hypotensive requiring vasopressors
- Suspected Infection
Exclusion
- Pregnant
- Liver Failure (ALT or AST \> 120)
- Rhabomyolysis (CPK \> 3x normal)
- Comfort care measures status
- Chronic Liver Disease (Cirrhosis)
- Use of Cyclosporin, Digoxin, Statins
- Patients who are unable to take medications by mouth or NGT
Key Trial Info
Start Date :
February 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT00676897
Start Date
February 1 2008
End Date
December 1 2010
Last Update
June 14 2017
Active Locations (1)
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1
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02446