Status:
COMPLETED
Transient Receptor Potential Vanilloid One (TRPV1) Receptor Expression in Children With Retrosternal Pain
Lead Sponsor:
Medical College of Wisconsin
Conditions:
Epigastric Pain
Retrosternal Pain
Eligibility:
All Genders
5-17 years
Brief Summary
We would like to evaluate the changes in nerve innervation and TRPV1 receptor expression along with microscopic changes associated with heart burn and abdominal pain
Detailed Description
Approximately 5% of children between 10-17 years of age report symptoms of heart burn, epigastric pain or regurgitation. This study will evaluate the changes in nerve innervation and TRPV1 receptor ex...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Retrosternal and/or epigastric pain and esophagitis
- Retrosternal and/or epigastric pain but no macroscopic or microscopic esophagitis
- Gastrointestinal symptoms such as diarrhea, regurgitation, rumination, vomiting, feeding aversion, non-organic failure to thrive, celiac disease with no macroscopic or microscopic esophageal inflammation
Exclusion
Key Trial Info
Start Date :
December 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2015
Estimated Enrollment :
77 Patients enrolled
Trial Details
Trial ID
NCT00677378
Start Date
December 1 2006
End Date
October 1 2015
Last Update
October 22 2015
Active Locations (1)
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1
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226