Status:
COMPLETED
Use of Functional Magnetic Resonance Imaging (fMRI) to Study Brain Activation in Children With Irritable Bowel Syndrome
Lead Sponsor:
Medical College of Wisconsin
Conditions:
Irritable Bowel Syndrome
Eligibility:
All Genders
10-18 years
Brief Summary
The purpose of the study is to map regions of brain activation following rectal stimulation in children with irritable bowel syndrome (IBS) and healthy controls.
Detailed Description
Our first aim is to compare the brain areas activated rectal stimulation in boys and girls with IBS and healthy children. Our second aim is to compare the anatomic regions of the brain activated durin...
Eligibility Criteria
Inclusion
- Children aged 10 years to 18 years who provide written assent and whose parents provide written permission for participation
- English-speaking
- Subjects in the IBS group will meet Rome III criteria for IBS as determined by a pediatric gastroenterologist.
Exclusion
- Other pain-related diseases, functional gastrointestinal disorders, or somatization disorder
- Mental retardation or pervasive developmental disorder or epilepsy
- Psychosis
- Genetic or chromosomal disorders
- Currently receiving psychoactive drug treatment
- Patients with pacemakers, metal clips used in previous surgery or other device which are not compatible with MRI scanning
- Inability to lie still in the scanner
- Claustrophobia (Inability to lie still in the scanner)
- Pregnancy
- Subjects who admit to substance abuse during screening
- Orthodontic braces
Key Trial Info
Start Date :
June 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2013
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT00677976
Start Date
June 1 2007
End Date
June 1 2013
Last Update
April 30 2020
Active Locations (1)
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1
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226