Status:
COMPLETED
A Pilot Study to Evaluate an Osteogenic Protein 1 (OP-1) Putty Spinal System and an Autograft Spinal System
Lead Sponsor:
Olympus Biotech Corporation
Conditions:
Degenerative Disc Disease
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
This study will explore the use of recombinant OP-1 in conjunction with surgical treatment of single-level TLIF of the lumbar spine.
Detailed Description
This pilot study is a randomized, multi-center, prospective, controlled study of the efficacy and safety of OP-1 Putty Spinal System in patients requiring a single level transforaminal interbody fusio...
Eligibility Criteria
Inclusion
- The patient is willing and able to understand, sign and date the study-specific, Institutional Review Board (IRB)/Independent Ethics Committee (IEC) approved patient informed consent and applicable privacy regulations.
- The patient has a documented diagnosis of DDD with up to Grade I spondylolisthesis demonstrated by radiographic imaging (by plain film/discography within 12 weeks of surgery and/or computed tomography (CT scan/magnetic resonance imaging \[MRI\].
- The patient requires single level lumbar fusion (L2 to S1)
Exclusion
- The patient has a history of previous surgery in the lumbar spine with or without attempted fusion {Note: a history of lumbar decompression surgery is permitted}.
- The patient has Grade II, Grade III or Grade IV spondylolisthesis.
- The patient has gross spinal instability measured on flexion/extension radiographs of \>25% translation of the vertebrae, or ≥20 degrees of angular motion or has significant (\>10%) scoliosis.
- The patient is receiving treatment (before, during or after surgery) with a drug that interferes with bone metabolism or is being treated with a bone growth stimulator.
- The patient has been treated in the last 6 months with radiation, chemotherapy, immunosuppression or systemic corticosteroids.
- The patient has a history of, or has any malignancy or spinal tumor of any type, with the exception of a history of a treated basal or squamous cell carcinoma.
- The patient is morbidly obese (defined as body mass index \[BMI\] \> 35).
- The patient currently uses tobacco products, within 3 weeks prior to time of treatment.
- The patient is known to require at the time of treatment, additional surgery to the lumbar spinal region within the next 6 months or has symptomatic multilevel degenerative disease requiring possible instrumented fusion of more than one level.
- The patient has previously been treated with or exposed to any Bone Morphogenetic Proteins (BMPs).
- The patient is contraindicated for iliac crest autografting in that the Investigator believes the patient would be unable to provide sufficient quantity or adequate quality autograft (e.g., osteoporosis as defined by this protocol) from a unilateral iliac crest harvest.
- The patient has a previous diagnosis of Paget's disease, osteomalacia or any other endocrine or metabolic bone disease that affects osteogenesis.
- The patient has a documented history of osteoporosis or has a risk of osteoporosis as defined by an Osteoporosis Risk Assessment Instrument (ORAI) score of ≥ 9 and a DEXA Scan T score of ≥-2.5 standard deviations below the normal range within one year of enrollment.
Key Trial Info
Start Date :
February 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2010
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00678171
Start Date
February 1 2007
End Date
March 1 2010
Last Update
February 5 2014
Active Locations (10)
Enter a location and click search to find clinical trials sorted by distance.
1
Los Angeles, California, United States, 90048
2
San Diego, California, United States, 92103
3
Durango, Colorado, United States, 81301
4
Boston, Massachusetts, United States, 02120