Status:
COMPLETED
The Effect of Atorvastatin on Renal Function in Healthy Subjects During Normal and High Sodium Intake
Lead Sponsor:
Regional Hospital Holstebro
Conditions:
Healthy Subjects
Eligibility:
All Genders
20-50 years
Phase:
PHASE4
Brief Summary
We wanted to test the hypothesis that acute treatment with atorvastatin changes renal sodium handling, renal hemodynamics, tubular function and vasoactive hormones in healthy humans during normal and ...
Detailed Description
We wanted to test the hypothesis that acute treatment with atorvastatin changes renal sodium handling, renal hemodynamics, tubular function and vasoactive hormones in healthy humans during normal and ...
Eligibility Criteria
Inclusion
- Age 20-50 yr
- BMI\<30
- Females had to use oral contraceptive treatment or IUD.
Exclusion
- Clinical signs or history of disease of the heart, lungs, kidneys, liver, brain or endocrine organs
- Abnormal laboratory blood tests (hemoglobin, sodium, potassium, albumin, creatinine, blood glucose, bilirubin, alanin amino transferase, alkalic phosphatase)
- Albuminuria or glucosuria
- cancer
- arterial hypertension
- alcohol abuse
- medical treatment, except contraceptives
- pregnancy or breast feeding
- blood donation one month before the study.
Key Trial Info
Start Date :
January 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2007
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT00678184
Start Date
January 1 2007
End Date
October 1 2007
Last Update
May 15 2008
Active Locations (2)
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1
Department of Medical Research, Holstebro Hospital
Holstebro, Denmark, 7500
2
Medical Research
Holstebro, Denmark, 7500