Status:
COMPLETED
Patients With Mouse Tyrp2 DNA: A Phase I Trial to Assess Safety and Immune Response
Lead Sponsor:
Memorial Sloan Kettering Cancer Center
Conditions:
Melanoma
Eligibility:
All Genders
7+ years
Phase:
PHASE1
Brief Summary
The goal of this study is to find out about the safety of injecting the gene (DNA) for mouse TYRP2 in patients with melanoma. DNA is a material that contains the information needed to produce many sub...
Eligibility Criteria
Inclusion
- For all patients, pathology slides must be reviewed by the Memorial Hospital Department of Pathology for confirmation of melanoma diagnosis.
- Patients must be HLA-A\*0201 positive.
- Patients must have a Karnofsky performance status of at least 80.
- Patients must be free of detectable brain metastases.
- Patients must have adequate organ and marrow function as defined below:
- WBC ≥ than or = to 3,000/μL
- Absolute neutrophil count ≥ than or = to 1,500/μL
- Platelets ≥ than or = to 100,000/μL
- Total bilirubin ≤ than or = to 1.5X upper normal institutional limits
- LDH ≤ than or = to 2 X institutional upper limit of normal
- Albumin ≥ than or = to 3.5 mg/dl
- Creatinine ≤ than or = to 2.0 mg/dl
- Hemoglobin ≥ than or = to 10 Gm/dl
- Liver AST, ALT ≤ than or = to 2.5 x ULN
- Patients must have no known HIV positivity
- Pediatric patients are eligible if weight is \> 25 kg and parent/guardian completes informed assent process.
- Patients must understand and sign an informed consent and have specifically declined all standard or approved therapies for which they would be considered eligible. Parent or legal guardians of patients who are minors will sign the informed consent form.
- As part of the consent process, patients must agree to use contraception while on study.
Exclusion
- Patients who have had chemotherapy, immunotherapy or radiotherapy within 4 weeks prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier. For nitrosoureas, at last six weeks must have elapsed.
- Patients with Grade I fever, active infection, or antibiotics within 72 hours prior to study.
- Patients who have previously been immunized with any class of vaccine containing TYRP2, including whole cell, shed antigen or cell lysate vaccine.
- Patients with a history of collagen vascular, rheumatological, or other autoimmune disorders.
- Any medical condition or use of medication (e.g., corticosteroids) which might make it difficult for the patient to complete the full course of treatments or to respond immunologically to vaccines is grounds for exclusion, at the discretion of the Principal Investigator or co-Principal Investigators.
- Patients who have preexisting retinal or choroidal eye disease.
- Patients with serious underlying medical conditions that could be exacerbated by participation, active infections requiring antimicrobial drugs or active bleeding.
- Pregnant women or women who are nursing are not eligible. Women of child-bearing potential and sexually active men must be using appropriate contraception during the course of this study. Women of child-bearing potential must not be pregnant (negative βHCG within 2 weeks of immunization) nor be nursing during treatment.
- Patients receiving other investigational agents.
Key Trial Info
Start Date :
July 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2011
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00680589
Start Date
July 1 2006
End Date
March 1 2011
Last Update
March 28 2011
Active Locations (1)
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1
Memorial Sloan-Kettering Cancer Center
New York, New York, United States, 10065