Status:
COMPLETED
Metabolic Effects of Androgenicity in Aging Men and Women
Lead Sponsor:
VA Office of Research and Development
Conditions:
Aging
Insulin Resistance
Eligibility:
MALE
60-85 years
Phase:
NA
Brief Summary
The goal of this research study is to study the effect of testosterone or estrogen on blood sugar control and fat metabolism. Changes in hormone levels with age may affect risk factors for heart disea...
Eligibility Criteria
Inclusion
- males age 60-85 years
- non-diabetic fasting glucose and 2-hour oral glucose tolerance test (OGTT)
- overall good general medical health and signed informed consent
- willing to travel to West Los Angeles VA and University of California, Los Angeles in Los Angeles, California
Exclusion
- any clinically significant abnormalities detected on screening physical exam or laboratory testing (e.g. prostate specific antigen \> 4)
- or other symptom or history of a significant underlying medical or psychiatric illness
- BMI \< 20 or \> 40
- subjects already on testosterone therapy or medications that might influence glucose regulation or hormone levels
- subjects with a history of deep venous thromboses, pulmonary embolism, breast cancer, prostate cancer, polycythemia or other contraindications to estrogen or testosterone
Key Trial Info
Start Date :
January 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2016
Estimated Enrollment :
33 Patients enrolled
Trial Details
Trial ID
NCT00680797
Start Date
January 1 2005
End Date
December 31 2016
Last Update
June 15 2017
Active Locations (1)
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1
VA Greater Los Angeles Healthcare System, West Los Angeles, CA
West Los Angeles, California, United States, 90073