Status:
COMPLETED
Gulf War Digestive Health Study
Lead Sponsor:
US Department of Veterans Affairs
Conditions:
Irritable Bowel Syndrome
Small Intestinal Bacterial Overgrowth
Eligibility:
All Genders
35-72 years
Phase:
NA
Brief Summary
The purposes of this study are to estimate the burden of disease due to chronic gastrointestinal illness in PG veterans, to evaluate whether Small Bowel Bacterial Overgrowth (SBBO) is associated with ...
Detailed Description
Approximately 700,000 United States military personnel were deployed in the first Persian Gulf (PG) War. Several months after their return, up to 25% of Veterans had persistent symptoms which they sus...
Eligibility Criteria
Inclusion
- Men and women age 32-75 years
- Rome III criteria for diarrhea-predominant IBS
- Symptom onset after an apparent episode of acute gastroenteritis
- Symptoms of \> 3 months duration
- Normal endoscopic appearance of the colonic mucosa
- Negative markers for celiac disease and inflammatory bowel disease.
- Normal thyroid function and serum calcium levels.
- Must have served in the military or reserves during the time of Operation Desert Storm (August 1990 to May 1991)
Exclusion
- Clinically significant cardiac, pulmonary, hepatic or renal dysfunction
- History of/or presence of systemic malignancy
- Current evidence of any gastrointestinal disorder such as celiac disease or inflammatory bowel disease (i.e. Crohns disease or ulcerative colitis)
- Current effects of drug or alcohol abuse
- Investigator perception of patients inability to comply with study protocol
- Unstable psychiatric disease
- Recent change in gastrointestinal medications
- Subjects with a positive pregnancy test
- Subject is currently participating in another research protocol that could interfere or influence the outcome measures of the present study
Key Trial Info
Start Date :
October 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2013
Estimated Enrollment :
54 Patients enrolled
Trial Details
Trial ID
NCT00680836
Start Date
October 1 2007
End Date
December 1 2013
Last Update
August 29 2014
Active Locations (1)
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1
Division of Epidemiology
Salt Lake City, Utah, United States, 84132