Status:
COMPLETED
Periodontal Infection and Endothelial Dysfunction
Lead Sponsor:
Universidad del Valle, Colombia
Conditions:
Periodontitis
Eligibility:
All Genders
25+ years
Phase:
PHASE3
Brief Summary
The purpose of this study is to determine the effect of periodontal therapy on endothelial function and other biomarkers of cardiovascular disease
Detailed Description
Periodontitis is one of the most prevalent chronic diseases and a frequent cause of tooth loss. Accumulation of subgingival dental biofilm in susceptible individuals is associated with an inflammatory...
Eligibility Criteria
Inclusion
- Subjects must be 25 years of age or older
- Three or more periodontal pockets with a probing depth (PD) \> 5mm
- Have at least 20 natural teeth
- Provide informed consent and willingness to cooperate with the study protocol
Exclusion
- History of antibiotic use in the previous three months
- Pregnant or lactating females
- Treatment with antihypertensive, antilipemic, antiarrhythmic, and other cardiovascular drugs
- Systemic diseases such as diabetes, HIV/AIDS, liver disease, chronic renal failure, tuberculosis, and autoimmune diseases
- Previous history of cardiovascular disease: Acute myocardial infarct, stable angina, unstable angina, heart failure, atrial fibrillation, atrioventricular block, peripheral vascular disease, cerebrovascular accident
- Patients who received periodontal treatment within the last 3 months
- Patients who require antibiotic prophylaxis before examination or treatment
- Patients with mental retardation and dementia
Key Trial Info
Start Date :
May 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2012
Estimated Enrollment :
102 Patients enrolled
Trial Details
Trial ID
NCT00681564
Start Date
May 1 2008
End Date
January 1 2012
Last Update
April 17 2014
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Red de Salud de Ladera E.S.E. Servicio de Odontología
Cali, Valle del Cauca Department, Colombia
2
Universidad del Valle, Facultad de Salud, Escuela de Odontología
Cali, Valle del Cauca Department, Colombia