Status:
UNKNOWN
Peptide Vaccination in Treating Patients With Esophageal Cancer
Lead Sponsor:
University of Yamanashi
Collaborating Sponsors:
Human Genome Center, Institute of Medical Science, University of Tokyo
Conditions:
Esophageal Cancer
Eligibility:
All Genders
20-80 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to evaluate the safety and immunological monitoring for peptide vaccination therapy using novel cancer testis antigens for locally advanced, recurrent, or metastatic esoph...
Detailed Description
We recently identified three HLA-A2402-restricted epitope peptides (TTK protein kinase (TTK), lymphocyte antigen 6 complex locus K (LY6K), and insulin-like growth factor (IGF)-II mRNA binding protein ...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS 1. Locally advanced, recurrent or metastatic esophageal squamous cell carcinoma who had failed for the standard therapy
- PATIENTS CHARACTERISTICS
- ECOG performance status 0-2
- Age≧20 years, 80≦years
- WBC≥ 2,000/mm³ Platelet count ≥ 75,000/mm³ Total bilirubin ≤ 2.0 x the institutional normal upper limits AST, ALT, ALP ≤ 2.5 x the institutional normal upper limits Creatinine ≤ 1.5 x the institutional normal upper limits
- Patients must be HLA-A2402
- Able and willing to give valid written informed consent
Exclusion
- Pregnancy (women of childbearing potential: Refusal or inability to use effective means of contraception)
- Breastfeeding
- Serious bleeding disorder
- Serious infections requiring antibiotics
- Concomitant treatment with steroids or immunosuppressing agent
- Decision of unsuitableness by principal investigator or physician-in-charge
Key Trial Info
Start Date :
August 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2009
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00682227
Start Date
August 1 2006
End Date
December 1 2009
Last Update
May 29 2008
Active Locations (1)
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1
University of Yamanashi, First Department of Surgery
1110 Shimokato, Chuo-city, Yamanashi, Japan, 409-3898