Status:
COMPLETED
Microarray Analysis of Sinus Samples From Patients With and Without Chronic Rhinosinusitis
Lead Sponsor:
University of California, San Francisco
Conditions:
Maxillary Sinusitis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Mucosal biopsies, endoscopically-guided brush samples of mucus, and a saline lavage taken from the maxillary sinuses of ten CRS patients undergoing sinus surgery are analyzed using three microarrays i...
Detailed Description
Mucosal biopsies, endoscopically-guided brush samples of mucus, and a saline lavage taken from the maxillary sinuses of ten CRS patients undergoing sinus surgery are analyzed using three microarrays: ...
Eligibility Criteria
Inclusion
- Inclusion Criteria (CRS patients):
- History of CRS as defined as symptoms (nasal discharge, nasal obstruction, facial pain and/or hyposmia) for \>12 weeks despite therapy.
- Impaired CRS-specific quality of life (SNOT-20 score \>1.5).
- Evidence of sinus disease on a CT scan (Lund MacKay score greater than or equal to 10).
- Patients with positive skin or RAST testing to an inhalant allergen and/or aspirin hypersensitivity will be included. Evidence of atopy is not required but will be recorded, along with serum IgE levels, when available.
- Inclusion Criteria (Control patients):
- No history of CRS
- SNOT-20 score \<1.0
- No evidence of sinus disease on preoperative imaging
- Exclusion Criteria:
- Control patients with any evidence of CRS, by history, survey, or imaging criteria would be excluded.
Exclusion
Key Trial Info
Start Date :
October 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 30 2008
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00683371
Start Date
October 1 2007
End Date
April 30 2008
Last Update
February 5 2020
Active Locations (1)
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1
University of California, San Francisco, Dept of Otolaryngology-HNS
San Francisco, California, United States, 94143