Status:
COMPLETED
Insulin and Polycystic Ovary Syndrome
Lead Sponsor:
Virginia Commonwealth University
Collaborating Sponsors:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions:
PCOS
Eligibility:
FEMALE
18-40 years
Phase:
NA
Brief Summary
Increased insulin levels leads to increased secretion of D-chiro inositol(DCI) from the kidneys in women with PCOS, but not in normal women. This leads to a reduction in circulating DCI and insulin st...
Eligibility Criteria
Inclusion
- Obese women with PCOS and normal women aged 18-40,
- PCOS less than 8 periods/year, elevated total or free testosterone, normal thyroid function tests and serum prolactin, exclusion of adrenal hyperplasia
- Normal regular monthly periods, no clinical evidence of androgen excess,
- All Acceptable health on interview, medical history, physical exams and lab tests, signed, witnessed informed consent and ability to comply to study requirements
Exclusion
- DM, clinically significant pulmonary, cardiac, renal, hepatic, neurologic, psychiatric, infectious, neoplastic or malignant disease.
Key Trial Info
Start Date :
November 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT00683774
Start Date
November 1 2005
End Date
December 1 2008
Last Update
June 14 2017
Active Locations (1)
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1
General Clinical Research Center
Richmond, Virginia, United States, 23298