Status:
COMPLETED
The Effects of Leucine on Body Weight
Lead Sponsor:
Columbia University
Conditions:
Overweight
Obesity
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Protein-rich diets appear to show some benefits in promoting weight loss. It is thought that increased intake of leucine may account for some of this effect. This study is designed to assess whether a...
Eligibility Criteria
Inclusion
- 18-65 year old overweight/obese
- healthy men and women
- Body Mass Index (BMI) of 28-35
Exclusion
- unusual or extreme dietary or exercise habits
- daily leucine supplement use
- inability to follow instructions to drink liquid meals
- type 1 diabetes or type 2 diabetes on drug treatment(diet controlled diabetics will be enrolled after consulting with their treating physicians)
- hypothyroidism or hyperthyroidism
- chronic wasting diseases (Acquired Immune Deficiency Syndrome (AIDS), cancers, cirrhosis, renal failure, Chronic Obstructive Pulmonary Disease (COPD), heart failure)
- drug or alcohol abuse
- tobacco smoker within the past 6 months
- pregnancy or lactating
- use of medications known to affect carbohydrate or lipid metabolism, satiety, or hunger
- anemia
- abnormal liver function tests (LFTs)
- women who are of child bearing age without adequate birth control modality
Key Trial Info
Start Date :
May 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2010
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT00683826
Start Date
May 1 2007
End Date
February 1 2010
Last Update
March 5 2013
Active Locations (1)
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1
Columbia University Medical Center
New York, New York, United States, 10032