Status:
COMPLETED
Renin-Guided Therapeutics in the Management of Untreated, Uncontrolled, or Complicated Hypertension
Lead Sponsor:
Medical University of South Carolina
Collaborating Sponsors:
New York Presbyterian Hospital
Conditions:
Hypertension
Eligibility:
All Genders
21+ years
Phase:
NA
Brief Summary
Plasma renin values determine whether volume or vasoconstrictor (renin) factors predominate in elevating blood pressure and are useful in selecting effective antihypertensive therapy.2,3 The research...
Detailed Description
Hypertension affects \~25% of adults. The prevalence of hypertension and related complications is greater among the elderly, obese, and ethnic minorities. Unfortunately, hypertension control rates rem...
Eligibility Criteria
Inclusion
- Age, 21 years of age and older
- Male or female (post-menopausal or effective method of birth control)
- BP and treatment criteria noted above
- Willingness to provide written, informed consent
- Ability to adhere to study protocol
Exclusion
- Uncontrolled diabetes or hyperlipidemia requiring medication changes
- Any active disease process requiring new diagnostic and therapeutic plans
- Any life-threatening illness
- History of alcohol or drug abuse in past 5 years
- Mental illness or personality disorder that interfere with adherence to study protocol
- Serum creatinine \>2.5 mg/dL unless documented stable for at least one year
- Dialysis for chronic renal failure, even if creatinine stable for at least one year
- Intolerance to two or more classes of antihypertensive medications
- Normal home BP (\<140/90 mmHg at baseline), i.e., office only hypertension.
Key Trial Info
Start Date :
September 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2005
Estimated Enrollment :
52 Patients enrolled
Trial Details
Trial ID
NCT00684489
Start Date
September 1 2003
End Date
September 1 2005
Last Update
May 26 2008
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.