Status:
COMPLETED
Cholecalciferol for Vitamin D in Adult Cystic Fibrosis (CF) Patients
Lead Sponsor:
Unity Health Toronto
Conditions:
Cystic Fibrosis
Vitamin D Deficiency
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The main aim of the research question to test the primary hypothesis of this study, namely, Does 12 weeks of an additional 5000 IU daily of cholecalciferol increase serum 25OHD levels in adults with C...
Detailed Description
Background and Significance Vitamin D is a fat-soluble vitamin necessary to maintain bone health as it maximizes calcium absorption from the gastrointestinal tract. Our primary source of vitamin D is ...
Eligibility Criteria
Inclusion
- older than 18 years of age
- diagnosis of CF by sweat testing/genetics
- vitamin D deficiency defined as a serum 25OHD level \< 75 nmol/L
- on stable baseline vitamin D supplementation for at least 2 months. Standard vitamin D supplementation (cholecalciferol) in CF includes 800 IU daily for individuals with pancreatic insufficiency and 400 IU daily for those with pancreatic sufficiency
Exclusion
- Individuals with known hypercalcemia or renal stones
- psychiatric history
- use of tanning beds/travel to sunny location within the last 2 months
- lung transplantation
- pregnancy or lactating women
Key Trial Info
Start Date :
December 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2013
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT00685971
Start Date
December 1 2008
End Date
July 1 2013
Last Update
November 21 2014
Active Locations (1)
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1
St. Michael's Hospital
Toronto, Ontario, Canada, M5B 1W8