Status:
COMPLETED
Hypothalamic Functional Magnetic Resonance Imaging (fMRI) Response to Nutrients
Lead Sponsor:
Oregon Health and Science University
Conditions:
Obesity
Eligibility:
All Genders
18-45 years
Phase:
PHASE2
Brief Summary
The purpose of this study is to identify how certain parts of the brain that control appetite respond to changes in dietary carbohydrate and fat.
Detailed Description
To measure fMRI signal change in hypothalamic and brainstem centers associated with control of food intake and energy expenditure in response to IV glucose, fructose, and saline. The fMRI response to ...
Eligibility Criteria
Inclusion
- Age 18 year to 45 years of age
- BMI 18 to 25 kg/m2 (25 subjects) and 30 to 40 kg/m2 (25 subjects), matched for age and sex.
- At maximal lifetime weight.
- Weight stable for at least 3 months.
Exclusion
- Those with a major medical illness or who require prescription medication, including: cancer, coronary artery disease, hypertension, and diabetes.
- Subjects taking psychiatric or centrally-acting (CNS) medications, or who are diagnosed with a psychiatric or neurological illness, including: depression, anorexia, bulimia, and seizure disorder.
- Subjects who have lost weight as a result of dieting, pharmacological treatment, or bariatric surgery.
- Weight \> 350 lbs or girth \> 60 inches (the limits of the MR machine)
- Exercise \> 30 minutes, 3 times a week.
- Alcohol consumption \> 2 drinks / day.
- Weight \> 300 lbs (150 kg) (weight limit for MR machine).
- Blood glucose \> 100 mg/dL, abnormal creatinine or liver function tests.
- Illicit drug use.
- Pregnancy.
- Extreme dietary habits as determined by a GCRC nutritionist: very high or low dietary carbohydrate, protein, or fat intakes.
- Those with a contraindication to exposure to strong magnetic fields: presence of metal in the body such as body piercing, shrapnel, cardiac pacemakers or aneurysm clips.
- Those with claustrophobia.
Key Trial Info
Start Date :
October 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2015
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT00686608
Start Date
October 1 2006
End Date
July 1 2015
Last Update
August 7 2019
Active Locations (1)
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1
Oregon Health & Science University
Portland, Oregon, United States, 97239