Status:
COMPLETED
Topical Dexamethasone and Tacrolimus for the Treatment of Oral Chronic Graft-Versus-Host Disease
Lead Sponsor:
Brigham and Women's Hospital
Collaborating Sponsors:
Dana-Farber Cancer Institute
Boston Children's Hospital
Conditions:
Oral Chronic Graft-versus-host Disease
Eligibility:
All Genders
4+ years
Phase:
PHASE2
Brief Summary
The purpose of this research study is to determine the effectiveness of topical steroid therapy (with a drug called dexamethasone) and topical tacrolimus therapy for the treatment of oral chronic Graf...
Detailed Description
* Because no one knows which study option is best, participants will be "randomized" into one of two study groups: topical dexamethasone or topical tacrolimus. * Participants will take the medication ...
Eligibility Criteria
Inclusion
- Patients with oral chronic graft-versus-host disease
- Patients 4 years of age or older
- Stable cGVHD medication regimen for the four weeks prior to study enrollment
Exclusion
- Patients already on topical steroid or tacrolimus therapies
Key Trial Info
Start Date :
August 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2013
Estimated Enrollment :
46 Patients enrolled
Trial Details
Trial ID
NCT00686855
Start Date
August 1 2008
End Date
March 1 2013
Last Update
March 20 2014
Active Locations (5)
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1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
2
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
3
Children's Hospital Boston
Boston, Massachusetts, United States, 02115
4
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02115