Status:
COMPLETED
Biomarker Study of Acamprosate in Schizophrenia
Lead Sponsor:
University of Maryland, Baltimore
Collaborating Sponsors:
National Alliance for Research on Schizophrenia and Depression
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Conditions:
Schizophrenia
Schizoaffective Disorder
Eligibility:
All Genders
18-55 years
Phase:
PHASE4
Brief Summary
NMDA receptors are brain receptors that are stimulated by glutamate. Poorly functioning NMDA receptors are thought to be involved in the pathology of schizophrenia. This hypothesis is based on the obs...
Detailed Description
We propose to measure the response of symptoms and cognition in people schizophrenia given acamprosate or placebo. We hypothesize that symptoms and cognition will improve following two weeks of acampr...
Eligibility Criteria
Inclusion
- DSM-IV diagnosis of schizophrenia/schizoaffective disorder
- Age 18-55 years
- Male or female
- Any Race/ethnicity
- Participants will be analyzed separately depending on whether they do or do not have a history of an alcohol use disorder
Exclusion
- Pregnant/nursing females or females not using adequate birth control
- Documented history of mental retardation/severe neurological disorder/head injury with loss of consciousness
- DSM-IV diagnosis of substance dependence in previous six months/abuse in the previous three months (except nicotine)
- Serious suicidal risk in the previous six months
- History of renal failure/creatinine clearance of less than 50mL/min
- Current treatment with clozapine
- Contraindication to MRI scanning.
Key Trial Info
Start Date :
June 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2012
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT00688324
Start Date
June 1 2008
End Date
February 1 2012
Last Update
September 25 2019
Active Locations (4)
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1
VA Maryland Health Care System
Baltimore, Maryland, United States, 21201
2
Keypoint Community Mental Health Centers- Dundalk
Baltimore, Maryland, United States, 21222
3
Keypoint Community Mental Health Centers- Catonsville
Baltimore, Maryland, United States, 21228
4
Maryland Psychiatric Research Center
Baltimore, Maryland, United States, 21228