Status:
COMPLETED
Effects of Crestor on Inflammation of Atherosclerotic Plaques
Lead Sponsor:
AstraZeneca
Conditions:
Atherosclerosis
Inflammatory Activity in Carotid Arteries
Eligibility:
All Genders
18-70 years
Phase:
EARLY_PHASE1
Brief Summary
The primary aim of this study is to investigate the effect of 40 mg dose of rosuvastatin on carotid plaque inflammation measured with MRI and PET scanning, to evaluate whether these techniques are pro...
Eligibility Criteria
Inclusion
- Subjects with a non-calcified plaque of at least 2 mm over an at least 6 mm length on first MR scan with an uptake of contrast agent on the dynamic MRI scan
- Signed written Informed Consent.
- Healthy men 18 - 70 years, women 60 - 70
Exclusion
- Use of a statin within six months before randomization.
- Use of lipid altering medication other than statins within the last six months.
- Clinical evidence of metabolic or vascular disease requiring statin or other lipid lowering pharmacological or non-pharmacological treatment.
- Total cholesterol \> 8, LDL-C \> 6 or TG \> 6 mmol/L at enrolment
Key Trial Info
Start Date :
December 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2009
Estimated Enrollment :
74 Patients enrolled
Trial Details
Trial ID
NCT00689416
Start Date
December 1 2007
End Date
June 1 2009
Last Update
June 30 2009
Active Locations (1)
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1
Research Site
Uppsala, Sweden