Status:
COMPLETED
A Comparison of Hydrochlorothiazide and Metolazone in Combination With Furosemide in Congestive Heart Failure Patients
Lead Sponsor:
University of New Mexico
Conditions:
Congestive Heart Failure
Eligibility:
All Genders
18-98 years
Phase:
NA
Brief Summary
Objective: To establish which combination of diuretics is the most effective in promoting diuresis in congestive heart failure patients. Secondary Objectives: To determine the duration of action of fu...
Eligibility Criteria
Inclusion
- Age \>18 years
- Diagnosis of chronic congestive heart failure with an ejection fraction ≤45%
- Currently on a stable regimen of furosemide consisting of a daily dose of at least 80 mg for at least two weeks.
- Patients receiving ACE-inhibitors and/or beta-blockers must be taking these medications for at least two weeks in stable doses.
Exclusion
- Renal dysfunction (serum creatinine \>2 mg/dl or creatinine clearance of \<30 ml/min as calculated by the Cockroft and Gault equation)
- Hepatic dysfunction (AST and ALT \>3 times the upper limit of the normal)
- Hypokalemia (\<4.0 mg/dl)
- Concomitant treatment with any diuretic other than furosemide (with the exception of spironolactone).
Key Trial Info
Start Date :
October 26 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 10 2009
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT00690521
Start Date
October 26 2004
End Date
November 10 2009
Last Update
October 10 2024
Active Locations (1)
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1
University Of New Mexico Hospital
Albuquerque, New Mexico, United States, 87120