Status:
COMPLETED
The Effect of Escitalopram on the Pharmacokinetics and Pharmacodynamics of Tramadol in Healthy Subjects
Lead Sponsor:
University of Southern Denmark
Collaborating Sponsors:
H. Lundbeck A/S
Conditions:
Healthy
Eligibility:
All Genders
18-45 years
Phase:
PHASE4
Brief Summary
Escitalopram will be given to a panel of 16 healthy subject for 9 days. On the ninth day a single dose of tramadol is administered to the subjects and pharmacokinetic(PK) and pharmacodynamic(PD) measu...
Eligibility Criteria
Inclusion
- Healthy
- Age: 18 - 45 years
- CYP2D6 phenotyped as extensive metabolizer
- CYP2C19 phenotyped as extensive metabolizer
Exclusion
- Alcohol or drug abuse
Key Trial Info
Start Date :
February 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2008
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT00692263
Start Date
February 1 2008
End Date
August 1 2008
Last Update
September 10 2008
Active Locations (1)
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1
Institute of Public Health, Clinical Pharmacology, University of Southern Denmark
Odense, Denmark, DK-5000