Status:
COMPLETED
Neuroimaging Attentional Impairment During Abstinence
Lead Sponsor:
Duke University
Collaborating Sponsors:
National Institutes of Health (NIH)
Conditions:
Smoking
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
The broad objective of this proposal is to identify functional neuroanatomical correlates of impairments in sustained attention during smoking abstinence. We will measure changes in performance and re...
Detailed Description
Following an extended training period in which performance will become stable, smokers will be tested in the 4 Tesla MRI scanner (GE LX NVi system) 24 hours after quitting smoking, and tested satiated...
Eligibility Criteria
Inclusion
- smoked an average of 10 cigarettes per day for two years
- a brand that delivers (by Federal Trade Commission rated yields) at least 0.5 mg nicotine
- have an expired air carbon monoxide reading of at least 10 ppm.
- be in general good health
- Participants with controlled medical conditions (e.g., hypertension) will be considered if treatment is not thought to interfere with fMRI measures or potentially ameliorate smoking withdrawal symptoms
Exclusion
- Individuals with a major medical condition that would make participation unsafe (e.g., have pacemaker or other metallic implant),
- uncomfortable (e.g., chronic pain),
- confound results (e.g., psychiatric condition)
- suffering from claustrophobia; abnormally afraid of closed-in places will be excluded from participation,
- Current alcohol or drug abuse,
- smokeless tobacco use, or use of nicotine replacement therapy or other smoking cessation treatment will also be a basis for exclusion and evaluated via a urine test.
Key Trial Info
Start Date :
June 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2009
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT00692406
Start Date
June 1 2005
End Date
January 1 2009
Last Update
March 28 2013
Active Locations (1)
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1
Duke University Medical Center
Durham, North Carolina, United States, 27705