Status:
COMPLETED
Clinical Significance of Collagen Metabolism Changes in Left Cardiac Ventricle
Lead Sponsor:
Charles University, Czech Republic
Collaborating Sponsors:
Ministry of Health, Czech Republic
Conditions:
Aortic Stenosis
Eligibility:
All Genders
18-75 years
Brief Summary
As there are no clinical data in cardiology about the relationship between metabolism collagen changes and their clinical significance, the investigators will check the hypothesis that collagen metabo...
Detailed Description
Clinical assessment and endpoints: 1ST day (the day of entering the hospital or the day of the first contact): Informed consent (see below), clinical examination, ECG, complete echocardiography evalu...
Eligibility Criteria
Inclusion
- isolated severe aortic stenosis (index aortic valve area less than 0,5 cm2/m2 or mean transaortic pressure gradient more than 40 mm Hg, assessed by echocardiography) and left ventricular hypertrophy (see above)
- signed informed consent
Exclusion
- presence of more than mild aortic regurgitation or other significant valvular lesion
- impossibility to obtain echocardiographic tracing of good quality
- all other diseases, which significantly influence collagen metabolism (renal failure, insulin dependent diabetes mellitus, bone diseases, hepatic failure)
Key Trial Info
Start Date :
January 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2009
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00693797
Start Date
January 1 2006
End Date
January 1 2009
Last Update
April 28 2009
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Faculty hospital Královské Vinohrady
Prague, Czechia, 100 34