Status:
COMPLETED
Exploring the Effects of Diazepam and Lorazepam
Lead Sponsor:
University Hospital, Strasbourg, France
Conditions:
Healthy Subjects
Eligibility:
All Genders
18-30 years
Phase:
NA
Brief Summary
Aims : * exploring lorazepam (0.038 mg/kg) effects, after a single oral intake, in healthy volunteers, on the neural correlates of encoding and retrieval of information during a word-stem completion ...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Healthy subjects between 18 and 30 years
- Students in medicine, dentistry or pharmacy
- French as a mother language
- Exclusion criteria:
- Medical condition influencing brain function (neurological or psychiatric)
- Asthma
- General anesthesia in the 3 last months
- Drug addiction (DSM IV criteria)
- Regular medical treatment (except contraceptive pill)
- Significant impairment observed during a medical examination including ECG
- Intake of any psychotropic drug that can have a effect during testing
- IQ (Wechsler) \< 100
- FMRI contra-indication (implantable magnetic material, claustrophobia)
- Known allergy to benzodiazepine or lactose
- \> 10 cigarettes/day
- Pregnant or breast-feeding woman
- No health insurance
- Subjects who do not complete the entire study
Exclusion
Key Trial Info
Start Date :
July 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT00696033
Start Date
July 1 2007
End Date
December 1 2008
Last Update
September 11 2025
Active Locations (2)
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1
Centre d'investigation clinique, hôpital civil
Strasbourg, France, 67091
2
Clinique psychiatrique, hôpital civil
Strasbourg, France, 67091