Status:
COMPLETED
PET Imaging of Peripheral Benzodiazepine Receptors
Lead Sponsor:
National Institute of Mental Health (NIMH)
Conditions:
Healthy
Eligibility:
All Genders
18+ years
Brief Summary
This study will use positron emission tomography (PET) to measure a receptor in the brain that is involved in inflammation. It will test two radioactive chemicals used in the procedure to see if the n...
Detailed Description
Objective: In response to brain inflammation, microglia over-express the peripheral benzodiazepine receptor (PBR). Although peripheral organs such as the heart and kidney express PBR constitutively, ...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Subjects must be healthy and at least 18 years of age.
- EXCLUSION CRITERIA:
- Current psychiatric disease, substance abuse or severe systemic disease based on history and physical exam.
- Laboratory tests with clinically significant abnormalities.
- Prior participation in other research protocols or clinical care in the last year such that radiation exposure, including that from this protocol, would exceed the guidelines set by the Radiation Safety Committee (RSC).
- Pregnancy or breast feeding.
- Positive result on urine screen for illicit drugs.
- Subjects who cannot lie on their back for extended periods of time.
- Subjects with significant claustrophobia who cannot tolerate an MRI scan.
- Subjects with cardiac pacemakers or metal in their bodies.
Exclusion
Key Trial Info
Start Date :
June 6 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 19 2014
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT00696371
Start Date
June 6 2008
End Date
August 19 2014
Last Update
December 17 2019
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892