Status:
COMPLETED
Serial Vasopressin and Copeptin Levels in Children With Sepsis and Septic Shock
Lead Sponsor:
Jan Hau Lee
Collaborating Sponsors:
National Medical Research Council (NMRC), Singapore
Conditions:
Sepsis
Septic Shock
Eligibility:
All Genders
1-16 years
Brief Summary
Patients with severe infection can develop very low blood pressure. There are many mechanisms leading to this, and one of them appears to involve a hormone called vasopressin. In children as compared ...
Eligibility Criteria
Inclusion
- Control Group:
- Neonates admitted for neonatal jaundice requiring phototherapy
- Previously well patients admitted for elective gastrointestinal endoscopy, patients admitted for non-specific abdominal pain and
- Pre-operative patients for circumcision, inguinal hernias and chronic orthopaedic conditions
- Study Group:
- The investigators will also enroll children with sepsis and septic shock
- Sepsis will be defined as proposed by the International pediatric sepsis consensus conference.
- Children will be recruited into the septic shock group if they have sepsis and features of cardiovascular organ dysfunction as defined by the same consensus conference.
Exclusion
- Neonates weighing less than 2.5 kg
- Neonates less than 36 weeks gestation
- Children more than 16 years of age
- Patients with a history of congenital heart disease
- Patients with chronic renal impairment
- Patients with chronic liver impairment
- Patients on active chemotherapy
- Patients on chronic mineralocorticoids or glucocorticoids therapy
- Patients on long-term diuretic therapy
- Patients with central nervous system tumours
- Patients with developmental delay
Key Trial Info
Start Date :
August 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
136 Patients enrolled
Trial Details
Trial ID
NCT00698048
Start Date
August 1 2008
End Date
December 1 2011
Last Update
September 9 2015
Active Locations (1)
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1
KK Women's and Children's Hospital
Singapore, Singapore, 229899