Status:
UNKNOWN
Chemotherapy on Methylation Patterns in Breast Tumor Tissue Correlating With Clinical Response and Outcomes
Lead Sponsor:
National University Hospital, Singapore
Conditions:
Breast Tumor Tissue
Eligibility:
FEMALE
21+ years
Brief Summary
Primary Objectives 1. To identify hypermethylated genes in paired pretreatment breast tumor tissue and plasma samples from locally advanced and metastatic breast cancer patients using a known gene pa...
Detailed Description
In advanced breast cancer, it is often difficult to predict which patients will respond favorably to systemic therapy to decide on treatment duration or options while minimizing exposure to toxic effe...
Eligibility Criteria
Inclusion
- We are not actively recruiting breast cancer patients but using stored biospy and plasma samples collected in the stated Clinical Trial (Phase II study of docetaxel combined with ketoconazole in the first-line treatment of locally advanced or metastatic breast cancer patients with measurable primary breast tumor) which was already IRB-approved
- For the normal controls, inclusion criteria are:
- Any female adult patient above 21
- No current or past history of underlying malignancies
Exclusion
- For normal controls, exclusion criteria are:
- (1) Past or current history of malignancies
Key Trial Info
Start Date :
October 1 2007
Trial Type :
OBSERVATIONAL
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00698477
Start Date
October 1 2007
Last Update
June 17 2008
Active Locations (1)
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1
National University Hospital
Singapore, Singapore