Status:
UNKNOWN
Effect of Dipeptidyl Peptidase-IV Inhibitor and Sulfonylurea on Glucose Variability and Oxidative Stress
Lead Sponsor:
The Catholic University of Korea
Collaborating Sponsors:
MSD Korea Ltd.
Conditions:
Type 2 Diabetes
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
This research will focus on the effect of Sitagliptin on 24 hour glycemic excursion and improvement of oxidative stress markers compared to long acting sulphonylurea Glimepiride in type 2 diabetic pat...
Detailed Description
Sitagliptin might improve not only the mean glycemic control during study period but also 24 hour glycemic fluctuation by restoring the physiologic pattern of insulin secretion. Furthermore decrease p...
Eligibility Criteria
Inclusion
- patients with type 2 diabetes
- duration of diabetes less than 10 years
- HbA1c 6.5-8.0%
- BMI 20-30
- on stable dose of metformin (more than 1000mg) for at least 2 months
Exclusion
- having oral hypoglycemic agents other than metformin
- using insulin
- serum creatinin \>= 1.5 mg/dL
- SGOT, SGPT \>= 90
- ischemic heart disease
- congestive heart failure (NYHA class \>=2)
- severe diabetic complication (PDR, CRF, CVA)
- on medication affecting glucose profile (such as steroid)
- infectious disease
- malignancy
- pregnant or breast-feeding woman
Key Trial Info
Start Date :
June 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2010
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT00699322
Start Date
June 1 2008
End Date
June 1 2010
Last Update
October 29 2009
Active Locations (1)
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1
Kangnam St. Mary's hospital
Seoul, South Korea, 137-701