Status:
WITHDRAWN
Influence of Pantoprazole on Human Myocardial Contractility at Patients With Congestive Heart Failure
Lead Sponsor:
Johann Wolfgang Goethe University Hospital
Conditions:
Congestive Heart Failure
Eligibility:
All Genders
18-80 years
Phase:
PHASE3
Brief Summary
Recently literature revealed facts, that show H+/K+ ATPase expression is not limited tot he stomach. H+/K+ ATPase was also found in smooth muscle cells and in other tissues (McCabe, R.D. et al., Am J ...
Detailed Description
Recently literature revealed facts, that show H+/K+ ATPase expression is not limited tot he stomach. H+/K+ ATPase was also found in smooth muscle cells and in other tissues (McCabe, R.D. et al., Am J ...
Eligibility Criteria
Inclusion
- Only patients older than 18 years. Range 18 to 80 years
- Only cooperative patients
- Only patients with a need for a coronary angiography, independently from our study
- Only patients with a left ventricular ejection fraction as demanded in the study protocol
- Only patients with clinical symptoms of congestive heart failure, corresponding to New York Heart Association stage NYHA II or III
- Only patients without oral or i.v. application of a proton pump inhibitor up to 48 hours prior to the study catheterization
Exclusion
- Manifest or severe accompanying diseases, despite of diabetes mellitus
- Intravascular or oral application of proton pump inhibitors within the last 48 hours
- Intake of Metformin within the last 24 hours
- Status post heart transplant
- Pregnancy
- Known intolerance of pantoprazole
- severe side effects of the tested substance pantoprazole, as well as pharmacokinetic interactions through CYP isoenzymes
- Existance of side effects as given in the pantoprazole drug information, among others disturbances of blood- and lymphatic system, leukopenia, thrombopenia, affections of gastrointestinal tract, nerve system affections, psychiatric affections, renal or bladder affections
- Participation in a other clinical trial
Key Trial Info
Start Date :
August 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00699361
Start Date
August 1 2008
End Date
December 1 2008
Last Update
February 11 2014
Active Locations (1)
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1
Johann Wolfgang Goethe University Hospitals, Department of Cardiology
Frankfurt am Main, Germany, 60590