Status:
COMPLETED
Prophylactic Olanzapine Versus Placebo for Prevention of Postoperative Delirium After Joint Replacement Surgery
Lead Sponsor:
The New England Baptist Hospital
Conditions:
Delirium
Eligibility:
All Genders
65+ years
Phase:
NA
Brief Summary
In this study we wanted to determine if perioperative administration of olanzapine prior to knee or hip replacement surgery in high risk patients would prevent the onset of postoperative delirium.
Detailed Description
Postoperative delirium is a serious and common (20% to 60%) complication in orthopedic surgery patients. In this study we investigate whether prophylactic administration of olanzapine can prevent deli...
Eligibility Criteria
Inclusion
- High risk for delirium age \> 65 history of delirium medical comorbidities ability to give informed consent
Exclusion
- Dementia Alcohol abuse Current use of an antipsychotic Allergy to olanzapine
Key Trial Info
Start Date :
January 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2007
Estimated Enrollment :
495 Patients enrolled
Trial Details
Trial ID
NCT00699946
Start Date
January 1 2005
End Date
October 1 2007
Last Update
January 21 2009
Active Locations (1)
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1
New England Baptist Hospital
Boston, Massachusetts, United States, 02120