Status:
COMPLETED
Statin Therapy for Ischemic and Nonischemic Cardiomyopathy
Lead Sponsor:
Philip Binkley
Collaborating Sponsors:
Pfizer
Conditions:
Cardiovascular Disease
Cardiomyopathy
Eligibility:
All Genders
18-85 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to see if taking a cholesterol lowering drug Lipitor (Atorvastatin Calcium)will increase the number of endothelial progenitor cells (EPC's) circulating in the blood of hea...
Detailed Description
This study involves the testing of blood for cholesterol levels and flow cytometry tests to count the number of EPC's in your blood. These tests are routinely performed to gain knowledge about a perso...
Eligibility Criteria
Inclusion
- Ischemic Cardiomyopathy (as defined above) with ejection fraction \< 35%
- Non-ischemic Cardiomyopathy with ejection fraction \< 35%
- NCEP ATPIII indication for therapy with a statin drug
- No statin therapy within previous 6 months of study enrollment
- Prescribed stable doses of standard heart failure therapies including beta blocking agents, angiotensin converting enzyme inhibitors or angiotensin receptor blockers, and diuretic agents as required
Exclusion
- Pregnant or lactating
- Myocardial infarction within 6 months preceding study enrollment
- Primary valvular heart disease
- Surgical or catheter based revascularization within the preceding 6 months
- Documented viral or inflammatory myocarditis or cardiomyopathy
- Peripartum cardiomyopathy
- Infiltrative cardiomyopathies
- Chemotherapy associated cardiomyopathy
- Without indication for statin therapy
- Contraindication to statin therapy including hepatic dysfunction, history of rhabdomyolysis or prior intolerance of statin therapy
- Contraindication to magnetic resonance imaging
Key Trial Info
Start Date :
April 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT00701220
Start Date
April 1 2007
End Date
December 1 2010
Last Update
July 18 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
The Ohio State University
Columbus, Ohio, United States, 43210