Status:
COMPLETED
Losartan in Hypertensive Men and Women With Sleep Apnea Before and on Continuous Positive Airway Pressure (CPAP) Treatment
Lead Sponsor:
Skaraborg Hospital
Collaborating Sponsors:
Göteborg University
Conditions:
Hypertension
Sleep Apnea
Eligibility:
All Genders
50-69 years
Phase:
PHASE4
Brief Summary
Obstructive sleep apnea (OSA) is a highly prevalent condition in hypertensive patients. The renin-angiotension-aldosterone-system (RAAS) has a central role in blood pressure control. An angiotensin-II...
Detailed Description
OSA is a highly prevalent condition in hypertensive patients and the prevalence is even higher in patients with drug-resistant hypertension. The renin-angiotension-aldosterone-system (RAAS) has a cent...
Eligibility Criteria
Inclusion
- Body Mass Index \<35 kg/m2
- Systolic Blood Pressure \>=140 mmHg and/or Diastolic Blood Pressure \>=95 mmHg
- No known clinical disease except hypertension
- No cardiovascular medication
- Apnea-Hypopnea Index \< 5/h (no OSA), or Apnea Hypopnea Index \>=15/h (OSA)
Exclusion
- Manifest diabetes, liver- or kidney disease Signs of atrial fibrillation or former myocardial infarction at electrocardiogram
Key Trial Info
Start Date :
June 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2014
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT00701428
Start Date
June 1 2008
End Date
February 1 2014
Last Update
October 22 2020
Active Locations (1)
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1
University of Gothenburg, Sahlgrenska Academy
Gothenburg, West Gotaland, Sweden, SE 41685