Status:
COMPLETED
Oral Isotretinoin for Photoaging: Results of a Randomized Controlled Phase II Trial
Lead Sponsor:
Federal University of São Paulo
Conditions:
Photoaging
Epidermal p53 Expression
Eligibility:
FEMALE
40-55 years
Phase:
PHASE2
Brief Summary
A clinical and histological randomized controlled phase II trial to evaluate the efficacy and safety of oral isotretinoin for treating photoaging was performed with 32 menopausal or sterilized women a...
Detailed Description
Clinical assessment ranging from -2=very bad to +2=very good for all patients. Also, profilometry, corneometer and skin elasticity tests in periocular regions and left forearm; skin biopsy on left for...
Eligibility Criteria
Inclusion
- menopausal or sterilized women
Exclusion
- woman at risk of pregnancy, with alterations on liver function or lipid profile
Key Trial Info
Start Date :
July 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2008
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT00701740
Start Date
July 1 2007
End Date
June 1 2008
Last Update
August 15 2018
Active Locations (1)
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1
Federal University of Sao Paulo
São Paulo, São Paulo, Brazil, 04023-900