Status:

TERMINATED

Bisoprolol in Patients With Heart Failure and Chronic Obstructive Pulmonary Disease

Lead Sponsor:

NHS Greater Glasgow and Clyde

Conditions:

Heart Failure

Chronic Obstructive Pulmonary Disease

Eligibility:

All Genders

18-90 years

Phase:

PHASE2

Brief Summary

The principal research objectives are to demonstrate cardioselective beta-blockade using bisoprolol is not inferior to placebo with regard to pulmonary function and improves quality of life in patient...

Eligibility Criteria

Inclusion

  • symptomatic NYHA II or III chronic heart failure
  • left ventricular systolic dysfunction
  • moderate or severe chronic obstructive pulmonary disease
  • with or without significant reversibility

Exclusion

  • beta-blocker contraindications
  • non-dihydropyridine (diltiazem / verapamil) calcium channel blockers
  • recent coronary percutaneous intervention or coronary artery bypass graft surgery
  • haemodynamically significant valvular disease or hypertrophic cardiomyopathy.
  • active myocarditis or pericarditis.
  • recent cerebrovascular accident or transient ischaemic attack
  • serious concurrent systemic disease, such as malignancy, resulting in likely reduced life expectancy
  • pregnancy, childbearing potential with inadequate contraception, breast feeding

Key Trial Info

Start Date :

March 1 2005

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

July 1 2008

Estimated Enrollment :

27 Patients enrolled

Trial Details

Trial ID

NCT00702156

Start Date

March 1 2005

End Date

July 1 2008

Last Update

September 3 2008

Active Locations (1)

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1

Cardiopulmonary Transplant Unit Glasgow Royal Infirmary

Glasgow, Scotland, United Kingdom, G31 2ER