Status:
COMPLETED
Pharmacokinetics of Piperacillin/Tazobactam in Patients Treated by Continuous Renal Replacement Therapy
Lead Sponsor:
University Hospital, Toulouse
Conditions:
Diffusive and Convective Clearance
Body Clearance
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The pharmacokinetics of piperacillin/tazobactam will be evaluated in twenty septic patients with renal failure undergoing continuous veno-venous hemodiafiltration.
Detailed Description
The pharmacokinetics of piperacillin/tazobactam will be evaluated in twenty septic patients with renal failure undergoing continuous veno-venous hemodiafiltration. This is a prospective study. Contin...
Eligibility Criteria
Inclusion
- 18 years of age and older .
- Females of childbearing potential must have a negative pregnancy test at screening.
- Subjects whose life expectancy is estimated over 7 days.
- Anuric patients requiring continuous venovenous hemodiafiltration
- Septic patients,severe sepsis or septic shock
- Written informed consent should be given either by the patient or a member of his family
Exclusion
- Subjects with a history of true allergy or adverse drug reactions
- Pathogens whose antibiotic susceptibility is not proved.
- Patients having impaired hepatic function
- Contraindication of anticoagulation by heparin
- Residual renal function
- Participation in a clinical trial
- Interruption of treatment by piper/tazo or hemodiafiltration during the study.
- Patients with psychiatric disorder or serious medical condition which in the opinion of the investigator may lead to complexity in patient management.
Key Trial Info
Start Date :
June 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2012
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00703144
Start Date
June 1 2008
End Date
August 1 2012
Last Update
January 24 2013
Active Locations (1)
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1
Service de Néphrologie
Toulouse, France, 31059