Status:
COMPLETED
Treatment-Resistant Depression, Hippocampus Atrophy and Serotonin Genetic Polymorphism
Lead Sponsor:
University of Ottawa
Conditions:
Major Depression
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
Reduction of volume of the hippocampus has been associated with major depression in many studies. It has been suggested that antidepressants may protect against hippocampus volume loss in humans assoc...
Detailed Description
Individuals who are defined as having treatment-resistant major depression (failure of at least 2 trials of an antidepressant at an adequate dose) and currently meet DSM-IV criteria for depression qua...
Eligibility Criteria
Inclusion
- Male or female between ages of 18 to 65 years of age.
- A diagnosis of Major Depression according to the DSM-IV criteria
- Failing to achieve remission while receiving at least two different antidepressants at adequate dosage for at least 6 weeks.
- Initial score of at least 18 on the HAMD-17 item rating scale
Exclusion
- A diagnosis of substance abuse or dependence in the last 6 months or a lifetime diagnosis of substance abuse according to the DSM-IV criteria, elicited by inquiry.
- A diagnosis of post-traumatic stress disorder, schizophrenia, schizo-affective disorder and other psychotic disorders, anorexia nervosa or a history of a manic or mixed episode
- Major medical illnesses including endocrine and neurological disorders, as well as a history of significant head trauma
- Exposure to oral or intravenous steroids
- Contraindications to magnetic resonance imaging
- An IQ less than 80
Key Trial Info
Start Date :
February 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT00704860
Start Date
February 1 2005
End Date
December 1 2010
Last Update
January 19 2011
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Ottawa Institute of Mental Health Research
Ottawa, Ontario, Canada, K1Z 7K4