Status:
COMPLETED
Metabolic Study of Sleep Apnea in Men and Women
Lead Sponsor:
University of Chicago
Collaborating Sponsors:
Duke University
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions:
Obstructive Sleep Apnea (OSA)
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
The purpose of this study is to look at the metabolic (use of energy) and hormonal features of sleep problems in men and women.
Detailed Description
Obesity is a major risk factor for obstructive sleep apnea (OSA), a condition characterized by repetitive respiratory disturbances, intermittent hypoxia, sleep fragmentation by frequent microarousals ...
Eligibility Criteria
Inclusion
- Obese (BMI of at least 30 kg/m2)
Exclusion
- Clinically significant depression
- Positive pregnancy test
- Diagnosis of diabetes mellitus
- Hypertension (systolic \> 140 mmHg and/or diastolic \> 90 mmHg) not well-controlled on stable medication with either ACE inhibitors or diuretics
- Habitual alcohol use
- Excessive caffeine intake of more than 300 mg/day
- Hemoglobin \< 11g/dL and/or hematocrit \< 33%
- Systemic illnesses, including heart, renal, liver, or malignant disease
- Taking steroid preparations (including oral contraceptives), medications known to alter insulin secretion and/or action, or medications known to influence sleep during the 2 months prior to starting the study
- Travel across time zones during the 4 weeks prior to starting the study
- Irregular sleeping habits (including shift work)
Key Trial Info
Start Date :
December 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 22 2012
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT00706511
Start Date
December 1 2007
End Date
August 22 2012
Last Update
March 24 2020
Active Locations (1)
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1
University of Chicago Department of Medicine, Section of Endocrinology, Diabetes & Metabolism
Chicago, Illinois, United States, 60637