Status:
COMPLETED
Circadian Variations in Ocular Blood Flow in Glaucomatous and Normal Eyes
Lead Sponsor:
Medical University of Vienna
Conditions:
Glaucoma, Open-Angle
Circadian Rhythm
Eligibility:
MALE
Brief Summary
After focusing many years only on intraocular pressure (IOP) as the primary risk factor, recently the impact of ocular blood flow is getting more consideration for the pathophysiology of glaucoma. The...
Eligibility Criteria
Inclusion
- For the glaucoma patients:
- Medical controlled Primary Open Angle Glaucoma with a history of more than 2 years
- Topical medication with beta-blockers (timolol, betaxolol, levobunol)
- IOP with medication \< 22 mmHg (with a medical history of IOP \> 22 mmHg)
- Visual field testing: mild glaucomatous defects (Humphrey 30-2 with MD\>10)
- Optic nerve head: C/D-ratio between 0.4 and 0.9
- ametropy \< 3 dpt
- Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant
- For the age matched control subjects:
- Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant
- Normal laboratory values unless the investigator considers an abnormality to be clinically irrelevant
- Normal ophthalmic findings, ametropy \< 3 dpt.
Exclusion
- For the glaucoma patients:
- History of trabeculectomy or laser trabeculoplasty
- Any other ocular disease with possible vascular involvement such as diabetic retinopathy, age related macular disease, retinal vein or artery occlusion.
- Uncontrolled systemic hypertension (defined as systolic blood pressure \> 170 mmHg or diastolic blood pressure \> 100 mmHg)
- Diabetes mellitus
- For the age matched control subjects:
- abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study
- Symptoms of a clinically relevant illness in the 3 weeks before the first study day
- History or presence of gastrointestinal, liver or kidney disease
- Ametropy \> 3 dpt
Key Trial Info
Start Date :
November 1 2000
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2001
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00707226
Start Date
November 1 2000
End Date
December 1 2001
Last Update
June 30 2008
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Clinical Pharmacology, Medical University of Vienna
Vienna, Austria, 1090