Status:
COMPLETED
Comparison of the Efficacy for Stress Ulcer Prophylaxis Between the Patients Received Lansoprazole OD and Control Group Weaning From Mechanical Ventilator in Respiratory Care Center: a Randomized Control Trial
Lead Sponsor:
Far Eastern Memorial Hospital
Conditions:
Respiratory Failure
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine whether lansoprazole administered nasogastrically is effective for stress ulcer prophylaxis in respiratory intensive care unit.
Detailed Description
Although stress ulcer is a complication that can cause mortality and morbidity in critical patients, there is still lack of consensus about its prophylaxis. There is also few data available from Taiwa...
Eligibility Criteria
Inclusion
- Initial ICU admission, APACHE II score ≥25。
- Evidence of IICP ( ICP monitor proved or brain CT proved edema)。
- Evidence of peptic ulcer disease ( A or H) proved by PES more than 3 months ago without PPI or H2 blocker agents therapy in recent one week。
- UGI bleeding history in ICU before transferring to RCC (proved by NG aspirate coffee ground substance or fresh blood ≥ 60 ml)。Not received PPI or H2 blocker agents in recent one week.
- Received NSAID for more than 7 days。
- Bleeding tendency or with major disease patients: coagulopathy, ESRD (CCR\<10), hematologic malignancy, liver cirrhosis Child C。
Exclusion
- Age \< 18 y/o, pregnancy。
- Active UGI bleeding and under PPI or H2-blockers。
- Family unwillings。
Key Trial Info
Start Date :
June 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2012
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT00708149
Start Date
June 1 2009
End Date
February 1 2012
Last Update
January 8 2013
Active Locations (1)
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1
Far Eastern Memorial Hospital
Taipei, Taiwan, 22050