Status:
TERMINATED
Does eNOS Gene Polymorphism Play a Role in the Maintenance of Basal Vascular Tone in the Choroid or Optic Nerve Head?
Lead Sponsor:
Medical University of Vienna
Conditions:
Ocular Physiology
Regional Blood Flow
Eligibility:
MALE
19+ years
Phase:
EARLY_PHASE1
Brief Summary
Nitric oxide (NO) is a potent endothelium-derived vasodilatator that plays a major role in the control of ocular blood flow. Endothelial NO synthase (eNOS) is one of three isoforms of NOS producing NO...
Eligibility Criteria
Inclusion
- Men aged between 19 and 35 years, nonsmokers
- Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant
- Homozygous variants of the T -786C genotyping (CC or TT)
- Normal ophthalmic findings, ametropia less than 3 diopters
Exclusion
- Regular use of medication, abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study
- Treatment in the previous 3 weeks with any drug
- Symptoms of a clinically relevant illness in the 3 weeks before the first study day
- History of hypersensitivity to the trial drug or to drugs with a similar chemical structure
- History or presence of gastrointestinal, liver or kidney disease, or other conditions known to interfere with, distribution, metabolism or excretion of study drugs
- Blood donation during the previous 3 weeks
Key Trial Info
Start Date :
May 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2013
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00708357
Start Date
May 1 2005
End Date
January 1 2013
Last Update
November 17 2014
Active Locations (1)
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1
Department of Clinical Pharmacology
Vienna, Austria