Status:
UNKNOWN
Tolerability And Efficacy Of High Dose Escitalopram In The Treatment Of Patients Suffering From Schizophrenia And Obsessive-Compulsive Disorder (OCD) - An Open Label Study
Lead Sponsor:
BeerYaakov Mental Health Center
Conditions:
OCD
Schizophrenia
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The purpose of the study is to evaluate tolerability and efficacy of escitalopram (Cipralex) treatment in doses beyond 20mg (20-40 mg/d) in patients with OCD and schizophrenia, non responsive or parti...
Eligibility Criteria
Inclusion
- All patients will be men and women over 18 years of age who meet DSM-IV criteria for schizophrenia/ schizoaffective disorder and OCD.
- Previous to entering the study all patients should be stabilized on antipsychotic medication for at least 3 months.
- Patients should score above 12 points on Yale Brown Obsessive Compulsive Scale (Y-BOCS) (Cut off point of Y-BOCS total score \> or =7 is the common practice in similar studies) (Kayahan et al 2005).
Exclusion
- All patients who are under antidepressant treatment (including SSRIs and clomipramine).
- In patients who were on clomipramine or SSRI in the past are included, at least 2 weeks must have been elapsed since stopping the medication.
- In case the patient has received an antidepressant which is not an SSRI or clomipramine, there will be a washout period of one week before entering the study.
- If the patient received a MAO-inhibitors there will be a washout period of at least 2 weeks except for fluoxetine for which a washout period of 5 weeks is required due to its long half-life.
- Known contraindication for the use of citalopram or escitalopram.
- Abnormal ECG findings at baseline
- Unable to understand and give informed consent.
Key Trial Info
Start Date :
July 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2010
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00708396
Start Date
July 1 2008
End Date
July 1 2010
Last Update
January 27 2009
Active Locations (1)
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1
Beer-Yaacov MHC
Beer-Yaacov, Israel, 70350