Status:
UNKNOWN
Effects of Iloprost on Hypoxic Pulmonary Vasoconstriction and Exercise Capacity at High Altitude
Lead Sponsor:
VA Loma Linda Health Care System
Collaborating Sponsors:
Actelion
Conditions:
Hypoxic Pulmonary Vasoconstriction
Eligibility:
MALE
18-80 years
Phase:
PHASE1
Brief Summary
The objective of this study is to determine if single dose administration of inhaled iloprost will reduce pulmonary artery pressure, reduce hypoxic pulmonary vasoconstriction and improve arterial oxyg...
Detailed Description
Three major pathways in addition to oxygen modulate pulmonary vascular tone: 1) nitric oxide, 2) endothelin, and 3) prostacyclin. Considerable animal data support the role of the prostacyclin pathway ...
Eligibility Criteria
Inclusion
- Age: 18 - 80 years
- Healthy physically active males or females
- Have readily measurable tricuspid regurgitation (TR) peak systolic velocity by continuous wave Doppler ultrasound
Exclusion
- Unable to measure TR velocity
- Known liver disease
- Pregnancy
- Nitrates, cyclosporin, glyburide or other medications that in the opinion of the investigators could place subjects at increased risk of complications
- Any other medical condition that in the opinion of the investigators would place the subject at high risk
Key Trial Info
Start Date :
July 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2008
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00708565
Start Date
July 1 2008
End Date
October 1 2008
Last Update
July 2 2008
Active Locations (1)
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1
Jerry L. Pettis VA Medical Center
Loma Linda, California, United States, 92357