Status:
WITHDRAWN
Spironolactone Versus Amiloride as an Add on Agent in Resistant Hypertension
Lead Sponsor:
VA Salt Lake City Health Care System
Conditions:
Hypertension
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Joint National Committee 7 (JNC-7) defines resistant hypertension as a persistent elevation of blood pressure (BP) above goal - ≥ 140/90 mm Hg for the general hypertensive population or ≥ 130/80 mm Hg...
Detailed Description
m/a
Eligibility Criteria
Inclusion
- Participants will be selected from a broad range of medical clinics at the Salt Lake City VA Medical Center and surrounding community based outpatient clinics (CBOCs).
- The participants will be referred to a resistant hypertension clinic by either their primary care provider or by a subspecialist. The referrals are made via a computerized system that is used in the Veterans Affairs Medical Center (VA) called Computerized Patient Record System (CPRS).
- Patients are referred if their blood pressure is above goal as defined by JNC 7 and they are on 3 antihypertensive medications with one of the agents being a diuretic.
- All patients age 18 -80 years old.
Exclusion
- Patients that will be excluded from the study if they have had a documented adverse reaction to either spironolactone or amiloride.
- diagnosis of primary hyperaldosteronism
- inability to adhere to frequent laboratory monitoring
- estimated glomerular filtration rate (GFR) \< 45 ml/min/1.73m2
- baseline serum potassium above 5.0 mEq/L
- type 4 renal tubular acidosis
- pregnancy
- heart failure that meets criteria for using either eplerenone or spironolactone
- current unstable renal function
Key Trial Info
Start Date :
October 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2010
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00709137
Start Date
October 1 2008
End Date
November 1 2010
Last Update
May 28 2014
Active Locations (1)
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1
VAMC SLC - George Wahlen VA
Salt Lake City, Utah, United States, 84148